Published June 2019
| Version v1
Journal article
Lung Stereotactic Arc Therapy in Mice: Development of Radiation Pneumopathy and Influence of HIF-1α Endothelial Deletion
Creators
- 1. Sorbonne Université, Collège Doctoral, Paris (France)
- 2. Institut de Radioprotection et de Sûreté Nucléaire, Service de Recherche en Radiobiologie et en Médecine régénérative, Laboratoire de Radiobiologie des expositions Médicales, Fontenay-aux-Roses (France)
- 3. Institut de Radioprotection et de Sûreté Nucléaire, Service de Recherche en Radiobiologie et en Médecine régénérative, Laboratoire de Radiobiologie des expositions Accidentelles, Fontenay-aux-Roses (France)
- 4. Institut de Radioprotection et de Sûreté Nucléaire, Service de Recherche en Radiobiologie et en Médecine régénérative, Fontenay-aux-Roses (France)
Description
Stereotactic body radiation therapy offers good lung local tumor control by the administration of a high dose per fraction in small volumes. Stereotactic body radiation therapy preclinical modeling is now possible, and our aim was to develop a model of focal irradiation of the mouse lung and to investigate the impact of conditional hypoxia-inducible factor 1α (HIF-1α) deletion in the endothelium on radiation-induced tissue damage.
Additional details
Identifiers
- DOI
- 10.1016/j.ijrobp.2019.01.081;
- PII
- S0360301619301725;
Publishing Information
- Journal Title
- International Journal of Radiation Oncology, Biology and Physics
- Journal Volume
- 104
- Journal Issue
- 2
- Journal Page Range
- p. 279-290
- ISSN
- 0360-3016
- CODEN
- IOBPD3
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 55057211
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ANOXIA; COMPUTERIZED SIMULATION; ENDOTHELIUM; IRRADIATION; LUNGS; MICE; NEOPLASMS; RADIOTHERAPY; THERAPEUTIC DOSES
- Descriptors DEC
- ANIMAL TISSUES; ANIMALS; BODY; DISEASES; DOSES; MAMMALS; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; RESPIRATORY SYSTEM; RODENTS; SIMULATION; THERAPY; VERTEBRATES
Optional Information
- Copyright
- Copyright (c) 2019 Published by Elsevier Inc.