Published May 1993 | Version v1
Journal article Metadata-only

The effect of heart-and kidney-Benefiting Chinese Herbal Medicine on the function of cholinergic M-and Gamma amino-butyric acid (GABA) receptor in brain tissues of analogue dementia rats

Creators

  • 1. Shanghai College of TCM, Shanghai (China)

Description

3H-QNB and 3H-GABA were used as radioactive ligand for M-and GABA receptors respectively. M-and GABA receptors were assayed by radioligand binding assay (RBA) in cerebral cortex, hippocampus and cerebellum of analogue dementia rats. It was found that Rt of M receptor was decreased in cerebral cortex and hippocampus and Rt of GABA receptor was decreased in cerebellum of analogue dementia rats. The dissociation constant (KD) of M-receptor was decreased significantly in cerebral cortex and KD value of (GABA) receptor was decreased in cerebellum of analogue dementia rats. The decreased Rt of M-and GABA receptor in brain tissue of analogue dementia rats was raised by Heart- and Kidney-Benefiting Chinese Herbs as well as hydergin

Additional details

Publishing Information

Journal Title
Nuclear Techniques
Journal Volume
16
Journal Issue
5
Journal Page Range
p. 295-298.
ISSN
0253-3219
CODEN
NUTEDL

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
25002708
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
AMINOBUTYRIC ACID; BRAIN; CHOLINE; ESTERS; LABELLING; LIGANDS; MEDICINAL PLANTS; RADIOPHARMACEUTICALS; RADIORECEPTOR ASSAY; RATS; RECEPTORS; TRITIUM
Descriptors DEC
ALCOHOLS; AMINES; AMINO ACIDS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; DRUGS; HYDROGEN ISOTOPES; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; LIPOTROPIC FACTORS; MAMMALS; MATERIALS; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PLANTS; QUATERNARY COMPOUNDS; RADIOACTIVE MATERIALS; RADIOASSAY; RADIOISOTOPES; RODENTS; TRACER TECHNIQUES; VERTEBRATES; YEARS LIVING RADIOISOTOPES