The clinical value and CT perfusion evaluation in chemotherapy combined with DC-CIK biological treatment of non-small cell lung cancer

Objective: To evaluate the value of chemotherapy combined with dendritic cell-cytokine induced killer (DC-CIK) bio-treatment in the treatmeat of non-small cell lung cancer (NSCLC) and to estimate the therapeutic results by multislice spiral CT lung perfusion. Methods: 30 cases of NSCLC patients who aged between 60 to 81 were collected, half male and half female, with an average age of 70.5 ± 2.1. The patients were randomly divided into the treatment (n = 15) and control groups (n = 15). The control group was treated with oxaliplatin + docetaxel chemotherapy, and the treatment group increased DC-CIK biological treatment on this basis. Multislice spiral CT lung perfusion was performed in all of the patients before and after treatment. The clinical response rate (RR) and clinical benefit rate (CBR) were compared between the two groups, and the CT perfusion indices were compared before and after treatment, including blood flow (BF), blood volume (BV), permeability surface (PS), peak time (TP) and mean transit time (MTT). Results: The total RR and CBR of the two groups were 70.0% and 96.7%. The RR and CBR in treatment group and control group were 46.7%, 93.3% and 93.3%, 100% respectively. Their differences had great statistical significance in RR between two groups (χ² = 9.210, P < 0.05). No significant difference could be observed on the CT perfusion indices before and after treatment in the control group. On the contrary, there were significant changes before and after treatment in the treatment group, which expressed as BF, BV, PS, TP were decreased and MTT was prolonged. There were significant differences between the two groups in CT perfusion indices after treatment. Conclusion: Chemotherapy combined with DC-CIK treatment can significantly improve the RR and CBR of non-small cell lung cancer than chemotherapy alone, and multi-slice spiral CT perfusion can effectively evaluate the therapeutic effect. (authors)