Published 1982
| Version v1
Book
A new method for labeling fibrinogen with 99m-technetium
Creators
- 1. Kantonsspital Basel (Switzerland)
- 2. University of Basel (Switzerland)
Description
Labeling of fibrinogen with 99m-Tc still is a problem, because of the pH-sensitivy of the protein. If the solution is too acid denaturation will take place, if it is too alkaline there will be hydrolysis. Therefore a control of the labeling rate is not sufficient, there must also be a control of the clottability of the fibrinogen. The pertechnetate-ion which is obtained by elution from a generator is reduced by tin(II) chloride in a solution of citric acid which is neutralized with sodium hydrogencarbonate. In this work the clottability of fibrinogen was tested by the method of Clauss, the labeling rate was determined by column chromatography
Additional details
Publishing Information
- Publisher
- Pergamon.
- Imprint Place
- Paris (France)
- ISBN
- 0-08-027089-1
- Imprint Title
- Nuclear medicine and biology
- Imprint Pagination
- 1172 p.
- Journal Page Range
- v. 1 p. 242-245.
Conference
- Title
- 3. World congress of nuclear medicine and biology.
- Dates
- 29 Aug - 2 Sep 1982.
- Place
- Paris (France).
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 14776344
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- FIBRINOGEN; LABELLING; LIQUID COLUMN CHROMATOGRAPHY; QUALITY CONTROL; RADIOPHARMACEUTICALS; TECHNETIUM 99
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BLOOD COAGULATION FACTORS; CHROMATOGRAPHY; CONTROL; DRUGS; GLOBULINS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SEPARATION PROCESSES; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES