Allelic polymorphism of DNA repair gene XRCC1 in patients with thyroid cancer who were exposed to ionizing radiation as a result of the Chornobyl accident
- 1. National Research Center for Radiation Medicine, NAMNU, Kyiv (Ukraine)
- 2. National Research Center for Radiation Medicine, NAMNU, Kyiv, DU Yinstitut Spadkovoyi Patologyiyi, NAMNU, L'vyiv (Ukraine)
Description
Frequency of minor allele Arg399Gln XRCC1 gene and homozygous carriers of this allele in patients with thyroid cancer, who were exposed to ionizing radiation due to Chornobyl disaster was significantly higher than in patients without exposure to ionizing radiation in anamnesis (0.57 and 0.37, p = 0.006 and 34.21 % and 7.81 %, p = 0.001, respectively). Comparing to the literature data on XRCC1 Arg399Gln polymorphisms in radiation-exposed individuals without cancer pathology, the risk of thyroid cancer in homozygous minor allele XRCC1 Gln399Gln carriers, who were exposed to ionizing radiation was significantly increased: OR = 4.14, p = 0.001 (CI95 % 1.72-9.93).The carrying of homozygous minor allele Gln399Gln of DNA repair gene XRCC1 is a risk factor for thyroid cancer under the influence of ionizing radiation in research group of Ukrainian population
Additional details
Additional titles
- Original title (Ukrainian)
- Adel'nij polyimorfyizm gena reparatsyiyi DNK XRCC1 u khvorikh na rak shchitopodyibnoyi zalozi, yakyi zaznali dyiyi yionyizuyuchoyi radyiatsyiyi vnaslyidok avaryiyi na Chornobil's'kyij AES
Publishing Information
- Publisher
- Kyiv 'DIA'
- Imprint Place
- Kyiv (Ukraine)
- Imprint Title
- Problems of radiation medicine and radiobiology
- Imprint Pagination
- 537 p.
- Journal Volume
- 19
- Series
- Zbyirnik naukovikh prats'
- Journal Page Range
- p. 377-388
- Report number
- INIS-UA--198
INIS
- Country of Publication
- Ukraine
- Country of Input or Organization
- Ukraine
- INIS RN
- 48028868
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Non-conventional Literature
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REPAIR; CHERNOBYLSK-4 REACTOR; DNA; IN VITRO; IONIZING RADIATIONS; NEOPLASMS; REACTOR ACCIDENTS; THYROID
- Descriptors DEC
- ACCIDENTS; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; BODY; DISEASES; ENDOCRINE GLANDS; ENRICHED URANIUM REACTORS; GLANDS; GRAPHITE MODERATED REACTORS; LWGR TYPE REACTORS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; POWER REACTORS; RADIATION EFFECTS; RADIATIONS; REACTORS; REPAIR; THERMAL REACTORS; WATER COOLED REACTORS
Optional Information
- Notes
- Imprint:Problemi radyiatsyijnoyi meditsini ta radyiobiologyiyi