Published 1994 | Version v1
Journal article Metadata-only

Liver calcium homeostasis modification by iron: A probable factor in its carcinogenesis

Creators

  • 1. Biophysics Laboratory, Medicine Faculty, Nancy University, Nancy (France)
  • 2. Biopharmacy Laboratory, Pharmacy Faculty, Nancy University, Nancy (France)
  • 3. Nuclear Medicine, University Medical Center, Nancy (France)
  • 4. Physiology Department, Medicine Faculty, Valladolid University, Soria (Spain)

Description

Low molecular weight iron complexes, ferric lactate and ferric-ATP complex, induce an important increase of Ca2+ - uptake by liver. The activity of ferric lactate increased by the presence of sodium ATP, and the steady high effect of ferric-ATP complex appear to indicate that ATP might play an important role in vivo formation of low molecular weight iron complexes that can induce the modification of the hepatocytes calcium homeostasis, the event that might be one of the factors triggering the malignant transformation. (author)

Additional details

Publishing Information

Journal Title
Neoplasma
Journal Volume
41
Journal Issue
4
Journal Page Range
p. 221-223
ISSN
0028-2685

INIS

Country of Publication
Slovakia
Country of Input or Organization
Slovakia
INIS RN
29060777
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Numerical Data
Descriptors DEI
AUTORADIOGRAPHY; CALCIUM 45; CARCINOGENESIS; DIAGNOSIS; EXPERIMENTAL DATA; HOMEOSTASIS; IRON COMPLEXES; LABELLED COMPOUNDS; LABELLING; MICE; NUCLEAR MEDICINE; RADIONUCLIDE KINETICS; STATISTICAL DATA; STATISTICS; TRACER TECHNIQUES; UPTAKE
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CALCIUM ISOTOPES; COMPLEXES; DATA; DAYS LIVING RADIOISOTOPES; EVEN-ODD NUCLEI; INFORMATION; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; MAMMALS; MATHEMATICS; MEDICINE; NUCLEI; NUMERICAL DATA; PATHOGENESIS; RADIOISOTOPES; RODENTS; TRANSITION ELEMENT COMPLEXES; VERTEBRATES

Optional Information

Notes
1 fig., 24 refs.