A new method for the preparation of 99mTc-stannous colloid instant kit

A new way for the preparation of 99mTc-stannous cooloid instant kit, its animal experimental results and its application to clinical practice were described. 500 mg sodium fluoride and 25 mg stannous chloride were dissolved in 50 ml sterile water, and the pH was adjusted to 6.4 with 0.05 mol/LHCl 0.5 millilitre of this solution was filtered into a vial and dryed under sterile condition. The kit can be used immediately after adding 2 ∼ 4 ml of 99mTcO4. It is suitable for intravenous administration as a imaging agent for liver or other organs of the reticuloerdothelial (RE) system. Distribution stadies of the 99mTc-stannous colloid in rats showed a rapid clearance of radioactivity from the blood stream and a subsequent rapid increase of radioactivity in the liver, up to approximately 90% of the injected dose. No toxic reactions were observed in rabbits at a dose of 1 ml of 99mTc-stannous colloid/kg