Published March 1981
| Version v1
Journal article
Synthesis of 11C-DL-tryptophan and its purification using high-pressure liquid chromatography
Creators
- 1. Franklin McLean Memorial Research Inst., Chicago, IL (USA)
Description
Carbon-11-DL-tryptophan has been produced from 11C-cyanide using a modified Bucherer-Strecker technique for synthesis and a high-pressure liquid chromatographic system for purification. More than 80 preparations have been run with an average radiochemical yield of 50% and synthesis and purification times of about 28 min. These modifications have significantly increased the level of 11C-tryptophan activity which is available for clinical use per mCi of 11C-cyanide. (author)
Additional details
Publishing Information
- Journal Title
- Int. J. Appl. Radiat. Isot.
- Journal Volume
- 32
- Journal Issue
- 3
- Series
- Int. J. Appl. Radiat. Isot.
- Journal Page Range
- 182-184
- ISSN
- 0020-708X
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 12606909
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CARBON 11; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; LABELLED COMPOUNDS; LIQUID COLUMN CHROMATOGRAPHY; PURIFICATION; TRYPTOPHAN
- Descriptors DEC
- AMINO ACIDS; AZOLES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CARBOXYLIC ACIDS; CHROMATOGRAPHY; EVEN-ODD NUCLEI; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; INDOLES; ISOTOPES; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRROLES; RADIOISOTOPES; SEPARATION PROCESSES; SYNTHESIS