Novel approaches to cancer targeting using epitope-binding properties that mimic monoclonal antibodies
Description
The investigators have extensive experience in all of the techniques required for this project including: animal models of tumors, quantitative autoradiography, radiochemistry, peptide synthesis, organic synthesis, molecular biology, kinetic modeling and radionuclide imaging both with single photon and PET agents. Preliminary results and progress in the following areas are presented: (1) Establishment of an in vivo tumor model and successful targeting of this tumor using monoclonal antibodies raised to p185erbB2, (2a) Screening of a synthetic peptide combinatorial library, (2b) Screening of a phage display peptide library, (3) Determination of the epitope recognized by ICR12, (4) Radiolabeling with 99mTc, 18F and *I (radioiodines), (5) High resolution positron emission tomography (PET) studies of tumors, and (6) Development of a high resolution (∼mm) PET camera
Availability note (English)
Available from INIS in electronic form; ALSO AVAILABLE FROM OSTI AS DE98006377; NTIS; US GOVT. PRINTING OFFICE DEP.
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Additional details
Publishing Information
- Imprint Pagination
- 19 p.
- Report number
- DOE/ER/62035--T1
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 30009218
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- EXPERIMENTAL DATA; EXPERIMENTAL NEOPLASMS; FLUORINE 18; ISOMERIC NUCLEI; MONOCLONAL ANTIBODIES; PEPTIDES; RADIOIMMUNOTHERAPY; RADIOPHARMACEUTICALS; TECHNETIUM 99
- Descriptors DEC
- ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; DATA; DISEASES; DRUGS; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; IMMUNOTHERAPY; INFORMATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MEDICINE; NANOSEC LIVING RADIOISOTOPES; NEOPLASMS; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOTHERAPY; TECHNETIUM ISOTOPES; THERAPY; YEARS LIVING RADIOISOTOPES
Optional Information
- Contract/Grant/Project number
- Contract FG02-95ER62035
- Funding organization
- USDOE Office of Energy Research, Washington, DC (United States)