Published 1987 | Version v1
Book Metadata-only

A brachytherapy model using /sup 125/I in a transplantable murine tumor

Creators

  • 1. Radiobiology Labs., Dartmouth-Hitchcock Medical Center, Hanover, NH 03756

Description

The effects of low dose rate irradiation (brachy-therapy) were investigated in vivo using a murine mammary adenocarcinoma (MTG-B). Transplanted tumors growing in the flanks of C3H mice were irradiated at diameters of 9.5-11 mm (0.45-0.70). A total of 8 experiments were performed over a 3 month interval. In each experiment two groups (radiation and sham controls) were analyzed, each containing 8-15 mice (N=137). A linear relationship was observed between the total dose and the mean growth delay (MGD). These results are compared to the MGD caused by 20 Gy of acute dose (517 cGy/min) x-rays in a single dose or 5 daily fractions of 4 Gy/fraction. These results suggest that this model is an appropriate system for brachy-therapy studies and is well suited for investigating interactions between low dose rate irradiation and hyperthermia and/or chemotherapy

Additional details

Publishing Information

Publisher
Radiation Research Society.
Imprint Place
Philadelphia, PA (USA)
Imprint Title
Thirty-fifth annual meeting of the Radiation Research Society (Abstracts)
Journal Page Range
p. 83.

Conference

Title
35. annual meeting of the Radiation Research Society.
Dates
22-26 Feb 1987.
Place
Atlanta, GA (USA).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
19040578
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S61: RADIATION PROTECTION AND DOSIMETRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference, Numerical Data
Descriptors DEI
BIOLOGICAL MODELS; BIOLOGICAL RADIATION EFFECTS; CARCINOMAS; CHEMOTHERAPY; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL DATA; EXPERIMENTAL NEOPLASMS; HYPERTHERMIA; IN VIVO; INTERACTIONS; IODINE 125; LOW DOSE IRRADIATION; MAMMARY GLANDS; MICE; RADIATION DOSES; RADIOLYSIS; RADIOTHERAPY; TRANSPLANTS; UPTAKE
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; BODY TEMPERATURE; CHEMICAL RADIATION EFFECTS; CHEMICAL REACTIONS; DATA; DAYS LIVING RADIOISOTOPES; DECOMPOSITION; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; GLANDS; INFORMATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; IRRADIATION; ISOTOPES; MAMMALS; MEDICINE; NEOPLASMS; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANS; RADIATION EFFECTS; RADIOISOTOPES; RODENTS; THERAPY; VERTEBRATES