Cardiac scintigraphy using absorbable radioactive microparticles
- 1. Comissao Nacional de Energia Nuclear de Brasil, Rio de Janeiro
Description
It was sought to experimentally demonstrate the possible complications and the results which could be obtained by myocardial scintigraphy in relation to blood flow in this region. Dogs weighing between 12 and 17kg were used. Under clinical and electrocardiographic control, a medium esternotomy was first performed, followed by the injection of 100-300 microcuries of 131I-labeled macroaggregates of human albumin, diameter 15 microns, into the left or right, or both, coronary arteries. A new series was then performed using microspheres labeled with 131I (microspheres have the advantage of being more homogeneous) and the results obtained were similar to those from the initial phase, thus confirming the conclusions. Another group of animals was studied by utilizing indium which was complexed to iron hydroxide. The assembled data suggest that myocardial scintigraphy can serve a useful technique for the study of coronary microcirculation
Abstract (French)
On a cherche a mettre en evidence, de facon experimentale, les complications possibles et les resultats qui peuvent etre obtenus par la scintigraphie myocardique en rapport avec la distribution du flux sanguin dans cette region. Utilisant des chiens pesant de 12 a 17kg, on a procede, sous controle clinique et electrocardiographique, a l'esternotomie moyenne et, ensuite, a l'injection d'une dose de 100 a 300 μCi des macro-agregats d'albumine humaine marquee a l'iode 131, avec diametre de 15 microns, dans les arteres coronaires droite et gauche ou dans les deux ensembles. Puis on a realise une nouvelle serie avec l'utilisation des microspheres marquees a l'iode 131 (les microspheres ont l'avantage d'etre presentees sous une forme plus homogene) et les resultats ont ete semblables a ceux de la premiere phase, confirmant les conclusions. Un autre groupe d'animaux a ete etudie avec l'emploi de l'indium complexe a l'hydroxyde de fer. Les donnees recueillies suggerent que la scintigraphie myocardique peut constituer une technique utile dans l'etude de la microcirculation coronaireAdditional details
Additional titles
- Original title (French)
- Scintigraphie cardiaque au moyen des micro-particules radioactives absorbables
Publishing Information
- Journal Title
- J. Radiol., Electrol., Med. Nucl.
- Journal Volume
- 56
- Journal Issue
- suppl.1
- Series
- J. Radiol., Electrol., Med. Nucl.
- Journal Page Range
- 248-250
Conference
- Title
- 9. Congress of latin country radiologists and 26. National congress of the Italian Society of Radiology and Nuclear Medicine.
- Dates
- 15 Oct 1974.
- Place
- Venice, Italy.
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 8293397
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- ALBUMINS; IODINE 131; MICROSPHERES; MYOCARDIUM; RADIOPHARMACEUTICALS; SCINTISCANNING
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DRUGS; HEART; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MEDICINE; MUSCLES; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES