Technetium-99m labelled LDL as a tracer for quantitative LDL scintigraphy. Pt. 1
- 1. Vienna Univ. (Austria). Clinic of Nuclear Medicine
- 2. Vienna Univ. (Austria). Dept. of Medical Chemistry
- 3. Austrian Research Center, Seibersdorf (Austria)
Description
The goal of the present study was to optimize technetium-99m labelling of low-density lipoprotein (LDL) and to investigate the in vitro and in vivo properties of the tracer to determine whether its application for quantitative scintigraphy of hepatic LDL receptor activity is feasible. Despite a high radiochemical purity immediately after labelling, modifications of 99mTc labelling of LDL did not overcome the poor stability of the tracer. Subsequent dialysis in phosphate buffer increased the stability in vitro and in vivo. It was concluded that dialysis substantially increases stability, which is essential for quantification purposes, and that the dialysed tracer retains its biological integrity as it is recognized by the LDL receptor in vitro
Additional details
Additional titles
- Subtitle (English)
- Tracer purification, in vitro and in vivo long-term stability, in vitro validation and biodistribution
Publishing Information
- Journal Title
- European Journal of Nuclear Medicine
- Journal Volume
- 20
- Journal Issue
- 8
- Journal Page Range
- p. 667-673.
- ISSN
- 0340-6997
- CODEN
- EJNMD9
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 25021789
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- COMPARATIVE EVALUATIONS; FEASIBILITY STUDIES; FIBROBLASTS; HEPATOMAS; IODINE 125; KINETICS; LABELLED COMPOUNDS; LIPOPROTEINS; LIVER; PATIENTS; RABBITS; RECEPTORS; SCINTISCANNING; STABILITY; TECHNETIUM 99; TISSUE DISTRIBUTION; TRACER TECHNIQUES
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARCINOMAS; CONNECTIVE TISSUE CELLS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; EVALUATION; GLANDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LIPIDS; MAMMALS; MAN; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PRIMATES; PROTEINS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SOMATIC CELLS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES