Published 1991 | Version v1
Journal article Metadata-only

Detection and cellular localization of lead by electron probe analysis in the diagnosis of suspected lead poisoning in rhesus monkeys

Creators

  • 1. Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland (USA)

Description

Lead poisoning of unknown source was diagnosed histologically in 2 rhesus monkeys (Macaca mulatta) by finding acid-fast intranuclear inclusion bodies in the epithelial cells of renal cortical tubules. The presence of lead in the inclusions was determined by scanning electron microscopy/energy dispersive x-ray analysis using sections from paraffin embedded tissues. This observation indicates the usefulness of this technique for the detection and cellular localization of lead in tissues, even from archival material

Additional details

Publishing Information

Journal Title
Toxicologic Pathology
Journal Volume
19
Journal Issue
1
Series
Toxicol. Pathol.
Journal Page Range
30-34
ISSN
0192-6233
CODEN
TOPAD

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
22080625
Subject category
S61: RADIATION PROTECTION AND DOSIMETRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ELECTRON MICROPROBE ANALYSIS; EPITHELIUM; LEAD; METABOLISM; MONKEYS; SCANNING ELECTRON MICROSCOPY; TISSUE DISTRIBUTION; TOXICITY; TUBULES
Descriptors DEC
ANIMALS; BODY; CHEMICAL ANALYSIS; DISTRIBUTION; ELECTRON MICROSCOPY; ELEMENTS; KIDNEYS; MAMMALS; METALS; MICROANALYSIS; MICROSCOPY; NONDESTRUCTIVE ANALYSIS; ORGANS; PRIMATES; TISSUES; VERTEBRATES