Published May 31, 2008
| Version v1
Journal article
HIV-1 integrase inhibitors as new components of antiviral therapy
- 1. A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University, Moscow (Russian Federation)
- 2. Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow (Russian Federation)
Description
Structural and functional features of HIV-1 integrase are considered and the state of the art in the quest for effective inhibitors of this enzyme is reported. The major classes of integrase inhibitors with known mechanisms of action as well as their in vitro and in vivo inhibitory activities are presented
Availability note (English)
Available from http://dx.doi.org/10.1070/RC2008v077n05ABEH003779Additional details
Identifiers
Publishing Information
- Journal Title
- Russian Chemical Reviews (Print)
- Journal Volume
- 77
- Journal Issue
- 5
- Journal Page Range
- p. 421-434
- ISSN
- 0036-021X
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 39105027
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- AIDS VIRUS; ENZYMES; IN VITRO; IN VIVO; THERAPY
- Descriptors DEC
- MEDICINE; MICROORGANISMS; ORGANIC COMPOUNDS; PARASITES; PROTEINS; VIRUSES