Published 1984 | Version v1
Book Metadata-only

Radiosensitivity, DNA repair, and DNA replication in cells derived from patients with ataxia telangiectasia

Creators

  • 1. Div. of Radiation Biology, Faculty of Pharmaceutical Sciences, Kanazawa Univ., Kanazawa 920

Description

This chapter deals with the authors' preliminary studies on a survey of radiosensitivity among the Japanese population involving use of cells derived from skin biopsies. The cells derived from Japanese AT homozygotes were significantly sensitive to X irradiation, whereas cells from AT heterozygotes were not radiosensitive. The D/sub O/ values of cells derived from apparently healthy individuals ranged from 148 to 166 R. They also analyzed the synthesis and repair of DNA in AT cells irradiated with X rays, by means of alkaline elution and host cell reactivation of γ-irradiated herpes simplex virus. Cells from AT patients showed a higher rate of DNA synthesis than control cells after 2 kR of X irradiation

Additional details

Publishing Information

Publisher
Academic Press Inc.
Imprint Place
Orlando, FL (USA)
ISBN
0-12-676020-9
Imprint Title
Modification of radiosensitivity in cancer treatment
Journal Page Range
vp.

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
19062780
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOPSY; CELL CULTURES; CELL DIVISION; DNA REPAIR; DNA REPLICATION; GENETIC RADIATION EFFECTS; HEREDITARY DISEASES; HERPES SIMPLEX; IRRADIATION; JAPAN; MUTAGENESIS; PATIENTS; RADIOSENSITIVITY; SKIN; X RADIATION
Descriptors DEC
ASIA; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; BODY; DEVELOPED COUNTRIES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; INFECTIOUS DISEASES; IONIZING RADIATIONS; NUCLEIC ACID REPLICATION; ORGANS; RADIATION EFFECTS; RADIATIONS; SKIN DISEASES; VIRAL DISEASES