Solid-supported synthesis of n-alkylated derivatives of 5-bromo pyrimidine-2, 4-dione and study of their cytotoxic effect

The presented study reports the synthesis of 5-bromo substituted pyrimidine-2,4-dione by conventional and solid-state microwave-assisted methodology. 5-bromo pyrimidine-2,4-dione derivatives represent the novel group of compounds possessing remarkable anti-tumor and anti-bacterial activities with significant therapeutic effects such as anti-neoplastic as well. Thus, a diversity-oriented convergent synthesis of complex organic molecules from simple and readily available substrates has been carried out that has resulted in the derivatization of 5-bromo pyrimidine-2,4 dione predominately giving N1 and N3 substituted compounds where R may be the alkyl, aryl, cyclohexyl methyl etc. In addition, use of solid-state microwave-assisted protocol proved to be of vital importance in terms of energy efficiency and designing a solvent-free ecofriendly synthetic route with considerably reduced reaction time. (author)