Published January 2004 | Version v1
Journal article Metadata-only

Radiolabelled DOTA-TATE: Its evaluation for targeted radiotherapy

Creators

  • 1. Radiopharmacy Departmenta, CIN, Faculty of Sciences and LOBBM, Montevideo (Uruguay)
  • 2. Radiopharmacy Departmenta, CIN, Faculty of Sciences and LOBBM, Montevideo (UY)
  • 3. Faculty of Medicine, Montevideo (UY)

Description

Development of radiopharmaceuticals for cancer therapy based on peptide molecules, which may be labelled with beta-gamma emitters, is an outstanding field of research. Among other peptides, (DOTA-D-phe-cys-tyr-D-trp-lys-thr-cys-thr), a somatostatin analogue with high affinity for somatostatin receptors expressed in cancer of neuroendocrine origin, may be labeled both with iodine as well as lanthanide radionuclides. In this study the labeling of DOTA-TATE with 125I and its biological properties were investigated, with the aim of its potential application as tumour-seeking agent

Availability note (English)

Also available online: www.wjnm.org

Additional details

Publishing Information

Journal Title
World Journal of Nuclear Medicine
Journal Volume
3
Journal Issue
suppl.1
Journal Page Range
p. S39-S40
ISSN
1450-1147

INIS

Country of Publication
International Atomic Energy Agency (IAEA)
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
35026195
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BRACHYTHERAPY; CARCINOMAS; LABELLED COMPOUNDS; MIBG; PEPTIDES; RADIATION SOURCE IMPLANTS; RADIOPHARMACEUTICALS
Descriptors DEC
AROMATICS; CARBONIC ACID DERIVATIVES; DISEASES; DRUGS; GUANIDINES; IMPLANTS; LABELLED COMPOUNDS; MATERIALS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PROTEINS; RADIATION SOURCES; RADIOACTIVE MATERIALS; RADIOLOGY; RADIOTHERAPY; THERAPY

Optional Information

Contract/Grant/Project number
Contract IAEA RC 12133/R0