Published January 2021 | Version v1
Journal article Metadata-only

Radiation-induced lymphopenia during chemoradiation therapy for non-small cell lung cancer is linked with age, lung V5, and XRCC1 rs25487 genotypes in lymphocytes

Creators

  • 1. Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha (China)
  • 2. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston (United States)
  • 3. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston (United States)

Description

Highlights: • Retrospective analysis of a clinical trial to identify predictors for RIL in NSCLC. • Age, lung V5 and XRCC1 rs25487 were independent risk factors for sereve RIL. • Number of these risk factors stratified patients at different risk for severe RIL. We investigated clinical and genetic factors associated with severe radiation-induced lymphopenia (RIL) in a randomized clinical trial of photon vs. proton radiation, with chemotherapy, for non-small cell lung cancer.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.radonc.2020.09.002

Additional details

Identifiers

DOI
10.1016/j.radonc.2020.09.002;
PII
S0167814020307714;

Publishing Information

Journal Title
Radiotherapy and Oncology
Journal Volume
154
Journal Page Range
p. 187-193
ISSN
0167-8140
CODEN
RAONDT

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
54013994
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CHEMOTHERAPY; CLINICAL TRIALS; GENOTYPE; HEALTH HAZARDS; LUNGS; LYMPHOCYTES; LYMPHOPENIA; NEOPLASMS; PATIENTS
Descriptors DEC
ANIMAL CELLS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; HAZARDS; HEMIC DISEASES; IMMUNE SYSTEM DISEASES; LEUKOCYTES; LEUKOPENIA; MATERIALS; MEDICINE; ORGANS; RESPIRATORY SYSTEM; SOMATIC CELLS; SYMPTOMS; TESTING; THERAPY

Optional Information

Copyright
Copyright (c) 2020 Elsevier B.V. All rights reserved.