Published January 27, 2007 | Version v1
Journal article Metadata-only

Structure of rat acidic fibroblast growth factor at 1.4 Å resolution

Creators

  • 1. ENKAM Pharmaceuticals A/S, Fruebjergvej 3, Box 58, DK-2100, Copenhagen (Denmark)
  • 2. Biostructural Research, Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen (Denmark)
  • 3. Protein Laboratory, Institute of Molecular Pathology, Panum Institute, Blegdamsvej 3C, DK-2200 Copenhagen (Denmark)

Description

The structure of rat acidic fibroblast growth factor was determined and compared with those of human, bovine and newt origin. The rat and human structures were found to be very similar. Fibroblast growth factors (FGFs) constitute a family of 22 structurally related heparin-binding polypeptides that are involved in the regulation of cell growth, survival, differentiation and migration. Here, a 1.4 Å resolution X-ray structure of rat FGF1 is presented. Two molecules are present in the asymmetric unit of the crystal and they coordinate a total of five sulfate ions. The structures of human, bovine and newt FGF1 have been published previously. Human and rat FGF1 are found to have very similar structures

Availability note (English)

Available from http://dx.doi.org/10.1107/S1744309107003144; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330123

Additional details

Identifiers

URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330123;
DOI
10.1107/S1744309107003144;
PII
S1744309107003144;

Publishing Information

Journal Title
Acta Crystallographica. Section F
Journal Volume
63
Journal Issue
Pt 2
Journal Page Range
p. 65-68
ISSN
1744-3091
CODEN
ACSFCL

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
46065539
Subject category
S75: CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY;
Descriptors DEI
CATTLE; CRYSTALS; FIBROBLASTS; MIGRATION; MOLECULES; ORIGIN; RATS; RESOLUTION; SULFATES
Descriptors DEC
ANIMAL CELLS; ANIMALS; CONNECTIVE TISSUE CELLS; DOMESTIC ANIMALS; MAMMALS; OXYGEN COMPOUNDS; RODENTS; RUMINANTS; SOMATIC CELLS; SULFUR COMPOUNDS; VERTEBRATES

Optional Information

Copyright
Copyright (c) International Union of Crystallography 2007
Notes
PMCID: PMC2330123; PMID: 17277441; PUBLISHER-ID: fw5120; OAI: oai:pubmedcentral.nih.gov:2330123