Published 2007
| Version v1
Journal article
Design and cytotoxic evaluation of new annonaceous acetogenin analogues
- 1. Universitaet Muenchen, Munich (Germany). Zentrum fuer Pharmaforschung Ludwig-Maximilians. Department Pharmazie
Description
Analogues of annonaceous acetogenins were built up from 5-iodofuran-2-carbaldehyde and undec-10-ynoic acid or undec-10-ynol by a Sonogashira reaction, followed by a Grignard reaction and a mercury catalysed hydratisation. The cytotoxicity was evaluated with MTT assay ((3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay for measuring cellular proliferation) against HL cells and at the National Cancer Institute (NCI). (author)
Availability note (English)
Available from http://www.scielo.br/pdf/jbchs/v18n4/03.pdfAdditional details
Identifiers
Publishing Information
- Journal Title
- Journal of the Brazilian Chemical Society
- Journal Volume
- 18
- Journal Issue
- 4
- Journal Page Range
- p. 691-695
- ISSN
- 0103-5053
- CODEN
- JOCSET
INIS
- Country of Publication
- Brazil
- Country of Input or Organization
- Brazil
- INIS RN
- 39082663
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Descriptors DEI
- ACETATES; ANTIMITOTIC DRUGS; BROMINE; CALORIMETRY; CARBON 13; ETHYL ETHER; FURANS; GAS CHROMATOGRAPHY; HEXANE; HYDROGEN 1; INFRARED SPECTRA; IODINE; MASS SPECTRA; NMR SPECTRA; SILICA GEL; THIAZOLES
- Descriptors DEC
- ADSORBENTS; ALKANES; AZOLES; CARBON ISOTOPES; CARBOXYLIC ACID SALTS; CHROMATOGRAPHY; DRUGS; ELEMENTS; ETHERS; EVEN-ODD NUCLEI; HALOGENS; HETEROCYCLIC COMPOUNDS; HYDROCARBONS; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; NONMETALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; SEPARATION PROCESSES; SPECTRA; STABLE ISOTOPES
Optional Information
- Notes
- 8 refs., 3 figs., 2 tab.