Analysis of the iron state in ferric and ferrous iron containing pharmaceutical products by Moessbauer spectroscopy

An analysis of the iron state in commercial pharmaceuticals containing ferric and ferrous iron compounds, which are used for treatment of iron deficiency, was made by Moessbauer spectroscopy. Small variations of the FeOOH cores of injectable iron-dextran complexes were observed. The presence of ferrous impurity in iron-dextran complexes was found. Characterization of the iron state in vitamins and dietary supplements containing ferrous compounds was made. The presence of ferrous and ferric impurities and iron compounds that were in disagreement with compounds announced by the manufacturer was detected by Moessbauer spectroscopy. (author)