Published September 2019 | Version v1
Journal article Metadata-only

Pencil Beam Scanning Proton Beam Chemoradiation Therapy With 5-Fluorouracil and Mitomycin-C for Definitive Treatment of Carcinoma of the Anal Canal: A Multi-institutional Pilot Feasibility Study

Creators

  • 1. Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston (United States)
  • 2. Department of Radiation Oncology, The University of Pennsylvania Cancer Center, Perelman School of Medicine, Philadelphia (United States)
  • 3. Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston (United States)

Description

Definitive chemoradiation with concurrent 5-fluorouracil (5-FU)/mitomycin C (MMC) is an effective treatment for localized anal cancer, but it is associated with significant acute long-term treatment-related toxicity. Pencil beam scanning proton beam (PBS-PT) radiation therapy may potentially reduce this toxicity. This is a multi-institutional pilot study evaluating the feasibility of definitive concurrent chemoradiation with PBS-PT in combination with 5-FU and MMC for carcinoma of the anal canal.

Additional details

Identifiers

DOI
10.1016/j.ijrobp.2019.04.040;
PII
S0360301619307473;

Publishing Information

Journal Title
International Journal of Radiation Oncology, Biology and Physics
Journal Volume
105
Journal Issue
1
Journal Page Range
p. 90-95
ISSN
0360-3016
CODEN
IOBPD3

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
55057342
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CARCINOMAS; FEASIBILITY STUDIES; FLUOROURACILS; MITOMYCIN; PROTON BEAMS; RADIOTHERAPY; TOXICITY
Descriptors DEC
ANTIBIOTICS; ANTI-INFECTIVE AGENTS; ANTIMETABOLITES; ANTIMITOTIC DRUGS; ANTINEOPLASTIC DRUGS; AZINES; BEAMS; DISEASES; DRUGS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; NUCLEON BEAMS; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PARTICLE BEAMS; PYRIMIDINES; RADIOLOGY; THERAPY; URACILS

Optional Information

Copyright
Copyright (c) 2019 Published by Elsevier Inc.