Continuous measurement of the lysis of 125I-labelled fibrin clots

Methods for continuous measurement of the dissolution of experimentally induced 125I-labelled thrombi were described. They are suited for the use in artificial circulating systems and in animal experiments. The radioactivity can be measured continuously in a circulating system by fitting a flow through cell with a well scintillator. In order to measure thrombolytic processes in vivo, a specially adapted single hole collimator was developed. By this device changes in radioactivity over a defined occluded area of the vessel could be detected. The usefulness of the methods was demonstrated by means of a thrombolytic agent. (author)