Radionuclide therapy of bone metastases in combination with surgical treatment, chemotherapy and bisphosphonates

The review is devoted to the palliative treatment of metastatic lesions of the bone system of cancer patients using radionuclide therapy (RNT) in combination with the methods of surgical and chemotherapeutic treatment, as well as the using of bisphosphonates. The article show a broad approach to this problem. The authors analyze the advantages and disadvantages of combining these therapies based on the literature data. It is shown that the surgical treatment, administration of chemotherapy and bisphosphonates can potentially improve the effect of subsequent RNT, however, the possibility of postoperative complications and the toxic effect of chemotherapy should be taken into account. In view of the foregoing, it is necessary to conduct individual planning of combined therapy depending on the condition of internal organs and the hemopoiesis system.