Published August 1978
| Version v1
Journal article
Theories on radiobiological effects
Creators
Description
Radiobiology has revealed two entirely dirrerent effects on irradiated cells. An early, interphase, death (α-effect) and also sublethal and potential lethal damage causing mitotic abnormalities leading to a delayed death (β-effect). The α-effect, caused by relative great ion densities, is now interpreted as a double break of the DNA molecule in the cell nucleus. The β-effect, caused by smaller ion densities, might be due to adjacent single breaks of the DNA. The nonlinear dose dependence of the β-effect can be explained by rapid rapair processes having alimited repair capacity. Slow repair of damaged normal cells in G1-phase can be enhanced by medical means and this might be important for clinical radiotherapy. (orig.)
Abstract (German)
Bestrahlte Zellen zeigen zwei ganz verschiedene Effekte. Bei einigen Zellen wird der Zellkern zerstoert und ein schneller Tod erfolgt (α-Effekt). Der α-Effekt wird heute als ein Doppelbruch des DNS-Molekuels im Zellkern erklaert, waehrend die β-Effekte auf eng benachbarte Einzelbrueche des DNS zurueckgefuehrt werden. Die nichtlineare Dosisabhaengigkeit des β-Effektes kann durch schnelle Reparationsvorgaenge mit begrenzter Kapazitaet erklaert werden. Langsame Reparationsvorgaenge an potentiell letalgeschaedigten Normalzellen, die sich in the G1-Phase befinden koennen durch spezielle Medikamente unterstuetzt werden. Dies kann fuer die klinische Strahlentherapie von Bedeutung sein. (orig.)Additional details
Additional titles
- Original title (German)
- Theorien ueber strahlenbiologische Wirkungen
Publishing Information
- Journal Title
- Roentgen Bl.
- Journal Volume
- 31
- Journal Issue
- 8
- Series
- Roentgen Bl.
- Journal Page Range
- 489-493
Conference
- Title
- 14. international congress on radiology.
- Dates
- 23 - 29 Oct 1977.
- Place
- Rio de Janeiro, Brazil.
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 10420803
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- ANIMAL CELLS; BIOLOGICAL REPAIR; BIOPHYSICS; CELL KILLING; DELAYED RADIATION EFFECTS; DNA; DOSE-RESPONSE RELATIONSHIPS; MATHEMATICAL MODELS; MITOSIS; MOLECULAR BIOLOGY; RADIATION INJURIES; RADIOBIOLOGY; STRAND BREAKS
- Descriptors DEC
- BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BIOLOGY; CELL DIVISION; DISEASES; INJURIES; NUCLEIC ACIDS; ORGANIC COMPOUNDS; RADIATION EFFECTS