Published December 2013 | Version v1
Journal article Metadata-only

Progress in diagnosis and treatment of radioactive iodine-refractory differentiated thyroid carcinomas

Creators

  • 1. Department of Oncology, the Affiliated Hospital of Qingdao University Medical College (China)

Description

During 131I therapy or the natural course of DTC, 2% to 5% of them will gradually no longer be sensitive to 131I therapy and lead to radioactive iodine-refractory DTC (RAIR-DTC). Recent studies found that alterations of critical molecular targets in main signal transduction pathways could decrease the iodine-trapping function of thyroid carcinoma, such as BRAFV600E mutation, followed by negative 131I-whole body scan (WBS) and discounted efficacy. This article reviews novel diagnostic and therapeutic modalities for RAIR-DTC. (authors)

Additional details

Publishing Information

Journal Title
Chinese Journal of Nuclear Medicine and Molecular Imaging
Journal Volume
33
Journal Issue
6
Journal Page Range
p. 505-509
ISSN
2095-2848

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
46111640
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BIOLOGICAL FUNCTIONS; CARCINOMAS; CAT SCANNING; DIAGNOSIS; FLUORINE 18; FLUORODEOXYGLUCOSE; IODINE; IODINE 131; ISONITRILES; MUTATIONS; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; RADIOTHERAPY; REVIEWS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; TECHNETIUM 99; THYROID; UPTAKE
Descriptors DEC
ANTIMETABOLITES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBONIC ACID DERIVATIVES; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DOCUMENT TYPES; DRUGS; ELEMENTS; EMISSION COMPUTED TOMOGRAPHY; ENDOCRINE GLANDS; FLUORINE ISOTOPES; GLANDS; HALOGENS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MEDICINE; NANOSECONDS LIVING RADIOISOTOPES; NEOPLASMS; NONMETALS; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOLOGY; TECHNETIUM ISOTOPES; THERAPY; TOMOGRAPHY; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
1 figs., 61 refs.