Quantitative determination of peripheral arterio-venous shunts by means of radioactively labelled microspheres
Description
In the present work a nuclear method of quantitative measurement of peripheral arterio-venous shunts with a whole-body scanner is standardized. This method, developed at the beginning of the 70s at Tuebingen, stands out in contrast with earlier measuring methods by the application of the theory of quantitative scintiscanning. This means that the scintigram obtained after injection of sup(99m)technetium-labelled human albumin microspheres into an artery before the shunt is corrected for the quantitative shunt calculation by several factors using a computer, to avoid systematic mistakes. For the standardization of the method, 182 scintigrams were taken during model experiments and experiments on animals and human beings. This method, having a deviation of 10% at most, is excellently suited for the quantitative determination of peripheral arterio-venous shunts. Already for a pulmonary activity of 3% a peripheral shunt is proved with 97.5% probability. (orig./MG)
Availability note (English)
MF available from INIS under the Report Number.Abstract (German)
In der vorliegenden Arbeit wird eine nuklearmedizinische Methode zur quantitativen Messung peripherer arterio-venoeser Shunts mit einem Ganzkoerperscanner standardisiert. Diese Methode, die Anfang der 70er Jahre in Tuebingen entwickelt wurde, zeichnet sich im Gegensatz zu frueheren Messmethoden durch die Anwendung der Theorie der quantitativen Szintigraphie aus. Dies bedeutet, dass das Szintigramm, das nach der Injektion von sup(99m)Tc-Humanalbumin-Mikrosphaeren in eine Arterie vor dem Shunt erhalten wird, zur quantitativen Shuntberechnung durch mehrere Faktoren mit einem Rechner korrigiert wird, um systematische Fehler zu vermeiden. Zur Standardisierung der Methode wurden 182 Szintigramme bei der Durchfuehrung von Modell- und Tierversuchen und Untersuchungen an Menschen aufgenommen. Die Methode ist mit einer Abweichung von hoechstens 10% sehr gut zur quantitativen Bestimmung peripherer arterio-venoeser Shunts geeignet. Bereits bei Lungenaktivitaeten von 3% ist ein peripherer Shunt mit einer Wahrscheinlichkeit von 97,5% bewiesen. (orig./MG)
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Additional details
Additional titles
- Original title (German)
- Quantitative Bestimmung peripherer arterio-venoeser Shunts mittels radioaktiv markierter Mikrosphaeren
Publishing Information
- Imprint Pagination
- 99 p.
- Report number
- INIS-mf--9135
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 15056289
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S61: RADIATION PROTECTION AND DOSIMETRY;
- Resource subtype / Literary indicator
- Thesis
- Descriptors DEI
- ALBUMINS; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; DATA PROCESSING; DIAGNOSIS; FISTULAE; INJECTION; MICROSPHERES; PATIENTS; RABBITS; RADIATION DOSES; RADIOPHARMACEUTICALS; SCINTISCANNING; SIDE EFFECTS; TECHNETIUM COMPOUNDS; TECHNETIUM 99; TOXICITY
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; HOURS LIVING RADIOISOTOPES; INTAKE; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPOUNDS; VERTEBRATES; YEARS LIVING RADIOISOTOPES