Published December 1, 2006
| Version v1
Journal article
Human thioesterase superfamily member 2 (hTHEM2) is co-localized with β-tubulin onto the microtubule
- 1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101 (China)
- 2. School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026 (China)
- 3. Key Laboratory of Molecular Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101 (China)
- 4. School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026 (China) and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101 (China)
Description
Human thioesterase superfamily member 2 (hTHEM2) belongs to the hotdog-fold enzyme superfamily but its biological function remains unknown. Tissue specific expression in mouse showed that the encoding gene is highly expressed in the kidney, and moderately expressed in the liver, brain, large intestine, and small intestine. Small interference RNA silencing in cell line HCT116 shows that the hthem2 gene is essential for the cell sustained proliferation. Immunostaining and GFP-Tag experiments show that hTHEM2 is co-localized with microtubules
Additional details
Identifiers
- DOI
- 10.1016/j.bbrc.2006.09.105;
- PII
- S0006-291X(06)02130-9;
Publishing Information
- Journal Title
- Biochemical and Biophysical Research Communications
- Journal Volume
- 350
- Journal Issue
- 4
- Journal Page Range
- p. 850-853
- ISSN
- 0006-291X
- CODEN
- BBRCA9
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 38027582
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- BIOLOGICAL FUNCTIONS; BRAIN; ENZYMES; GENES; KIDNEYS; LARGE INTESTINE; LIVER; MICE; MICROTUBULES; RNA; SMALL INTESTINE
- Descriptors DEC
- ANIMALS; BODY; CELL CONSTITUENTS; CENTRAL NERVOUS SYSTEM; DIGESTIVE SYSTEM; GASTROINTESTINAL TRACT; GLANDS; INTESTINES; MAMMALS; NERVOUS SYSTEM; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RODENTS; VERTEBRATES
Optional Information
- Copyright
- Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.