Published November 1, 2010 | Version v1
Journal article Metadata-only

Using neutron protein crystallography to understand enzyme mechanisms

Creators

  • 1. Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111-2497 (United States)
  • 2. Bioscience Division, MS M888, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)
  • 3. Chemistry Department, University of Toledo, Toledo, OH 43606 (United States)
  • 4. Institut Laue-Langevin, 6 Rue Jules Horowitz, BP 156, 38042 Grenoble CEDEX 9 (France)

Description

A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated d-xylose isomerase. A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated d-xylose isomerase. These represent four stages in the progression of the biochemical catalytic action of this enzyme. Analyses of the structural changes observed between the various three-dimensional structures lead to some insight into the mechanism of action of this enzyme

Availability note (English)

Available from http://dx.doi.org/10.1107/S0907444910027915; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967424

Additional details

Identifiers

URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967424;
DOI
10.1107/S0907444910027915;
PII
S0907444910027915;

Publishing Information

Journal Title
Acta Crystallographica. Section D: Biological Crystallography
Journal Volume
66
Journal Issue
Pt 11
Journal Page Range
p. 1257-1261
ISSN
0907-4449
CODEN
ABCRE6

INIS

Country of Publication
Denmark
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
46057561
Subject category
S75: CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY;
Descriptors DEI
CRYSTALLOGRAPHY; IONS; NEUTRON DIFFRACTION; NEUTRONS
Descriptors DEC
BARYONS; CHARGED PARTICLES; COHERENT SCATTERING; DIFFRACTION; ELEMENTARY PARTICLES; FERMIONS; HADRONS; NUCLEONS; SCATTERING

Optional Information

Copyright
Copyright (c) International Union of Crystallography 2010
Notes
PMCID: PMC2967424; PMID: 21041947; PUBLISHER-ID: dz5207; OAI: oai:pubmedcentral.nih.gov:2967424