Published April 1993
| Version v1
Journal article
Radioimmunoimaging of human breast carcinoma xenografts in nude mouse model with 111In-labeled new monoclonal antibody EBA-1 and F(ab')2 fragments
- 1. Met-Path Inc., Teterboro, NJ (United States)
- 2. Columbia Univ., New York, NY (United States)
Description
Radioimmunoimaging characteristics of a new monoclonal antibody EBA-1 and its F(ab')2 fragments utilizing nu/nu mice bearing human breast carcinoma xenografts are described. 111In-DTPA conjugates of EBA-1 localized with tumor/blood ratios of 0.99 ± 0.10 (P < 0.3) and 4.65 ± 1.60 (P < 0.05), and localization indices of 1.25 and 2.61 at 24 and 72 h, respectively. A tumor/blood ratio as high as 28.86 ± 6.90 (P < 0.025) was obtained with EBA-1 G(ab')2 radioconjugates at 48 h. These results suggest that EBA-1 and its F(ab')2 might be useful reagents in radioimmunoimaging and radioimmunotherapy. (author)
Additional details
Publishing Information
- Journal Title
- Nuclear Medicine and Biology
- Journal Volume
- 20
- Journal Issue
- 3
- Journal Page Range
- p. 325-335.
- ISSN
- 0883-2897
- CODEN
- NMBIEO
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 24069631
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CARCINOMAS; DTPA; IMMUNOTHERAPY; INDIUM 111; LABELLED COMPOUNDS; MAMMARY GLANDS; MONOCLONAL ANTIBODIES; RADIOIMMUNODETECTION; RADIOTHERAPY
- Descriptors DEC
- AMINO ACIDS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CHELATING AGENTS; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; GLANDS; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MEDICINE; MINUTES LIVING RADIOISOTOPES; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOASSAY; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; THERAPY; TRACER TECHNIQUES