Electrospun nanofibers modified with zeolitic imidazolate framework-8 for electrochemiluminescent determination of terbutaline

For the first time it is demonstrated that zeolitic imidazolate framework-8 electrospun nanofibers (ZIF-8 NF) could serve as electrochemiluminescence (ECL) accelerator for the facile detection of terbutaline residual. A novel ECL sensor for the determination of terbutaline was fabricated based on ZIF-8 NF. The ZIF-8 NF were successfully prepared according to electrospinning and in-situ growth method. First, chitosan was modified on the surface of the electrode, and then the ZIF-8 NF was modified onto the upper layer of the chitosan. Taking advantages of chitosan and ZIF-8 NF in conductivity and electrocatalysis, the modified electrode presents obvious ECL phenomenon in 0.2 M PBS solution (pH 10.0) containing 0.025 M luminol. After the addition of terbutaline, ECL intensity decreased significantly, and the decreasing value showed a linear relationship with the logarithm of terbutaline concentration. The linear range was from 2.0 × 10⁻¹⁰ to 2.0 × 10⁻⁵ M, and the detection limit was 1.41 × 10⁻¹¹ M (3σ/m). The method had high sensitivity, good stability, and good applicability to actual pork samples.