Published February 1987
| Version v1
Journal article
Molecular characterization of 15 rearrangements among 90 human in vivo somatic mutants shows that deletions predominate
Description
Ninety hypoxanthine phosphoribosyltransferase-deficient mutants were isolated from lymphocytes of 31 individuals drawn from both control populations and populations exposed to low doses of ionizing radiation. Southern analysis of the DNA revealed altered hybridization patterns in 15 mutants. Of these, 14 changes consisted of deletions of 2 to 40 kilobases or more
Additional details
Publishing Information
- Journal Title
- Mol. Cell. Biol.
- Journal Issue
- no.2
- Series
- Mol. Cell. Biol.
- ISSN
- 0270-7306
- CODEN
- MCEBD
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18072842
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- CHROMOSOMES; DNA; GENETIC MAPPING; GENETIC RADIATION EFFECTS; GLYCOSYL TRANSFERASES; HYBRIDIZATION; IONIZING RADIATIONS; LYMPHOCYTES; MUTATIONS; RADIATION EFFECTS; RADIATION INJURIES
- Descriptors DEC
- ANIMAL CELLS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; ENZYMES; GENETIC EFFECTS; INJURIES; LEUKOCYTES; MATERIALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; RADIATIONS; SOMATIC CELLS; TRANSFERASES