Interaction between tetracycline and microorganisms during wastewater treatment: A review

Highlights: • The activity of function strain recovers after adapting to tetracycline (• Sludge protects itself with extracellular polymers which offer adsorption sites. • The biochemical adsorption process is rapid, but involves ion competition. • A lag period is needed before a cometabolism-led biodegradation process. • The integrated coupling system has the higher tetracycline mineralization rate. Tetracycline (TC) is a commonly used human and veterinary antibiotic that is mostly discharged into wastewater in the form of the parent compounds. At present, wastewater treatment plants (WWTPs) use activated sludge processes that are not specifically designed to remove such pollutants. Considering the biological toxicity of TC in aquatic environment, the migration and fate of TC in the process of wastewater treatment deserve attention. This paper reviews the influence of TC on the functional bacteria in the sludge matrix and the development of tetracycline-resistant genes, and also discusses their adsorption removal rates, their adsorption kinetics and adsorption isotherm models, and infers their adsorption mechanism. In addition, the biodegradation of TC in the process of biological treatment is reviewed. Co-metabolism and the role of dominant bacteria in the degradation process are described, along with the formation of degradation byproducts and their toxicity. Furthermore, the current popular integrated coupling-system for TC degradation is also introduced. This paper systematically introduces the interaction between TC and activated sludge in WWTPs. The review concludes by providing directions to address research and knowledge gaps in TC removal from wastewater.