Published June 2005 | Version v1
Journal article Metadata-only

Preparation of [66Ga]bleomycin complex as a possible PET radiopharmaceutical

Creators

  • 1. Nuclear Research Center for Agriculture and Medicine, Karaj (Iran, Islamic Republic of). Cyclotron/Nuclear Medicine Dept.
  • 2. Nuclear Research Center for Agriculture and Medicine, Karaj (Iran, Islamic Republic of). SSDL/Health Physics Dept.
  • 3. Nuclear Research Center for Agriculture and Medicine, Karaj (Iran, Islamic Republic of). Ion Beam Application Dept.

Description

Gallium-66 (T1/2 = 9.49 h) is an interesting radionuclide that has potential use for positron emission tomography (PET) imaging of biological processes in intermediate to slow target tissue uptake. 66Ga was produced in the NRCAM cyclotron as a result of 15 MeV proton bombardment of 66Zn with current intensity of 180 μA (yield 11.2 mCi/μAh). Bleomycin (BLM) was labeled with [66Ga]GaCl3 for its possible diagnostic properties. The complex formation yield was optimized for pH, time, temperature, and ligand : radioactivity ratio. Radio-TLC showed an overall radiochemical yield of >98% (radiochemical purity >98%). The stability of the complex was checked in vitro. (author)

Additional details

Publishing Information

Journal Title
Journal of Radioanalytical and Nuclear Chemistry
Journal Volume
264
Journal Issue
3
Journal Page Range
p. 617-621
ISSN
0236-5731
CODEN
JRNCDM

INIS

Country of Publication
Hungary
Country of Input or Organization
Hungary
INIS RN
36061546
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BLEOMYCIN; CHEMICAL REACTION KINETICS; GALLIUM 66; GALLIUM COMPLEXES; POSITRON COMPUTED TOMOGRAPHY; PROTON REACTIONS; RADIOPHARMACEUTICALS; ZINC 66 TARGET
Descriptors DEC
ANTI-INFECTIVE AGENTS; ANTIBIOTICS; ANTIMITOTIC DRUGS; ANTINEOPLASTIC DRUGS; BARYON REACTIONS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CHARGED-PARTICLE REACTIONS; COMPLEXES; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; GALLIUM ISOTOPES; HADRON REACTIONS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MATERIALS; NUCLEAR REACTIONS; NUCLEI; NUCLEON REACTIONS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; REACTION KINETICS; TARGETS; TOMOGRAPHY

Optional Information

Notes
28 refs.