Deep learning-based dynamic PET parametric K${}_i$ image generation from lung static PET

PET/CT is a first-line tool for the diagnosis of lung cancer. The accuracy of quantification may suffer from various factors throughout the acquisition process. The dynamic PET parametric K${}_i$ provides better quantification and improve specificity for cancer detection. However, parametric imaging is difficult to implement clinically due to the long acquisition time (∼1 h). We propose a dynamic parametric imaging method based on conventional static PET using deep learning. Based on the imaging data of 203 participants, an improved cycle generative adversarial network incorporated with squeeze-and-excitation attention block was introduced to learn the potential mapping relationship between static PET and K${}_i$ parametric images. The image quality of the synthesized images was qualitatively and quantitatively evaluated by using several physical and clinical metrics. Statistical analysis of correlation and consistency was also performed on the synthetic images. Compared with those of other networks, the images synthesized by our proposed network exhibited superior performance in both qualitative and quantitative evaluation, statistical analysis, and clinical scoring. Our synthesized K${}_i$ images had significant correlation (Pearson correlation coefficient, 0.93), consistency, and excellent quantitative evaluation results with the K${}_i$ images obtained in standard dynamic PET practice. Our proposed deep learning method can be used to synthesize highly correlated and consistent dynamic parametric images obtained from static lung PET. Compared with conventional static PET, dynamic PET parametric K${}_i$ imaging has been shown to provide better quantification and improved specificity for cancer detection. The purpose of this work was to develop a dynamic parametric imaging method based on static PET images using deep learning. Our proposed network can synthesize highly correlated and consistent dynamic parametric images, providing an additional quantitative diagnostic reference for clinicians.