The study of the mechanism producing radioresistant state of hemopoietic system under the infleunce of diethylstylbestrol

The effect of diethylstylbestrol on the hematopoietic system of intact animals and on dynamics of post-radiation hematopoiesis recovery was studied. The injection of diethylstylbestrol into unirradiated animals was shown to induce the decrese in CFUs and CFU-GM content in bone marrow, the increase in granulocyte-macrophage precursors number in spleen, the decrease in proliferative activity of hematopoietic precursor cells and the rise of CSF-GM levels in the sera at the period of optimal manifestation of radioprotective effect. Mice, which were protected by diethylstylbestrol, deonstrated much more powerful recovery of CFUs, CFU-GM numbers as well as myeloid and erythroid hematopoiesis series in comparison with irradiated control animals