Published August 2017
| Version v1
Journal article
Synthesis and evaluation of anticancer and PDE 5 inhibitory activity of spiro-substituted quinazolin-4-ones
Creators
- 1. Minia University, Chemistry Department, Faculty of Science (Egypt)
- 2. Al-Azhar University, Organic Chemistry Department, Faculty of Pharmacy (Egypt)
Description
A series of novel spiro-substituted 2,3-dihydroquinazolin-4(1H)-ones was synthesized and structurally confirmed by spectral analysis, screened for their anticancer activity at a concentration of 10 μΜ against a panel of 56 cell lines derived from nine different types of cancers, including leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and breast cancers. The synthesized compounds screened for their PDE 5 inhibitory activity and it showed encouraged activity compared to sildenafil. Graphical abstract: .
Additional details
Identifiers
Publishing Information
- Journal Title
- Monatshefte fuer Chemie
- Journal Volume
- 148
- Journal Issue
- 8
- Journal Page Range
- p. 1513-1523
- ISSN
- 0026-9247
- CODEN
- MOCHAP
INIS
- Country of Publication
- Austria
- Country of Input or Organization
- Austria
- INIS RN
- 49073942
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Descriptors DEI
- ABUNDANCE; CONCENTRATION RATIO; KIDNEYS; LARGE INTESTINE; LEUKEMIA; LUNGS; MAMMARY GLANDS; MELANOMAS; OVARIES; PROSTATE
- Descriptors DEC
- BODY; CARCINOMAS; DIGESTIVE SYSTEM; DIMENSIONLESS NUMBERS; DISEASES; EPITHELIOMAS; FEMALE GENITALS; GASTROINTESTINAL TRACT; GLANDS; GONADS; IMMUNE SYSTEM DISEASES; INTESTINES; MALE GENITALS; NEOPLASMS; ORGANS; RESPIRATORY SYSTEM
Optional Information
- Copyright
- Copyright (c) 2017 Springer-Verlag Wien