Clinical analysis of 260 patients with nodular goiter and hyperthyroidism treated by ¹³¹I

Objective: To study the treatment effect of ¹³¹I in nodular goiter and hyperthyroidism. Methods: The thyroid nodules numbers and iodine absorption rate in 260 patients confirmed with nodular goiter and hyperthyroidism were determined, and the patients were treated with ¹³¹I and followed-up for 3 to 60 months. The patients were then given levothyroxine sodium 25-150 g/day based on their health situation to inhibit the increase TSH and hypothyroidism. Results: The curative rate of hyperthyroidism with ¹³¹I treatment was 65.39%, and partial rate was 20.0%, and hypothyroidism rate was 14.61%. After ¹³¹I treatment, 78.85% of nodules was eliminated, nodular narrow accounted for 15.39% and nodular invalid accounted for 5.77%. The curative effect of smaller diameter nodal was better than larger ones (P < 0.05). Conclusion: ¹³¹I therapy is suitable method for nodular goiter and hyperthyroidism treatment with good curative effect, especially for patients with surgery contraindication. (authors)