Published August 2006 | Version v1
Journal article Metadata-only

Preparation and evaluation of 99Tcm-HYNIC-annexin V for apoptosis imaging

Creators

  • 1. China Inst. of Atomic Energy, Beijing (China). Dept. of Isotope
  • 2. Beijing Univ. First Hospital, Beijing (China). Dept. of Nuclear Medicine

Description

Bifunctional chelating agent succinimidyl 6-tert-boc-hydrazinopyridine-3-carboxylic acid (HYNIC) is synthesized and successfully applied in the conjugating and radiolabelling of Annexin V. One molecular of Annexin V is conjugated with two molecular of HYNIC. The labelling ratio of the labelled compound is 98%, and the radiochemical purity of 95% is remained after 6 h. 99Tcm-HYNIC-Annexin V has been successfully evaluated in animal models and the results show that the cell apoptosis can be assayed by which. (authors)

Additional details

Publishing Information

Journal Title
Journal of Isotopes
Journal Volume
19
Journal Issue
3
Journal Page Range
p. 140-145
ISSN
1000-7512

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
38083154
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
APOPTOSIS; CARBOXYLIC ACIDS; CHELATING AGENTS; CHEMICAL PREPARATION; CONTRAST MEDIA; EVALUATION; IMIDES; IMPURITIES; LABELLED COMPOUNDS; LABELLING; PROTEINS; PYRIDINE; TECHNETIUM 99
Descriptors DEC
AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIDINES; RADIOISOTOPES; SYNTHESIS; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
7 figs., 1 tab., 4 refs.