Formation and prevention of amyloids having implications in neurodegenerative diseases: thermal analysis in obtaining biophysical insights

Aggregation and misfolding in proteins is associated with neurodegenerative disorders such as, Alzheimer's, Parkinson's, Huntington's and prion diseases. Accumulation of protein fibrils leads to amyloidosis, though recently their catalytic properties are also being explored in combination with metals. Cross-β sheet quaternary structures are adopted by the amyloids. The effect of anticancer drugs on fibrillation/aggregation properties of the transport protein bovine serum albumin has been studied to understand how molecules act as inhibitors in the process of aggregation