Published November 2007 | Version v1
Book Metadata-only

Comparison of 131I-TYR3-octreotate and 131I-DOTA-TYR3-octreotate: The effect of DOTA on pharmacokinetics and stability

Creators

  • 1. Institute of Energetic and Nuclear Research, IPEN-CNEN, Sao Paulo (Brazil)

Description

The authors compared the biodistribution, and in vivo and in vitro stabilities of 131I-Tyr3-octreotate and 131I-DOTA-Tyr3-octreotate. The peptides were radioiodinated by the chloramine T method and high radiochemical yields were obtained (greater than 97%). Both labelled compounds showed high stability when incubated in human plasma at 37 deg C. The 131I-Tyr3-octreotate showed significant hepatic uptake and biliary excretion. The biodistribution of 131I-DOTA-Tyr3-octreotate, however, can be compared with the distribution of radiometal labelled octreotide analogues. (author)

Part of:
Trends in Radiopharmaceuticals (ISTR-2005). Proceedings of an International Symposium. Vol. 2

Additional details

Identifiers

URL
http://www-pub.iaea.org/MTCD/publications/PDF/Pub1294_vol2_web.pdf;

Publishing Information

Publisher
IAEA
Imprint Place
Vienna (Austria)
ISBN
92-0-101707-3
Imprint Title
Trends in radiopharmaceuticals (ISTR-2005). Proceedings of an international symposium. Vol. 2
Imprint Pagination
476 p.
Series
Proceedings series
Journal Page Range
p. 243-251
ISSN
0074-1884

Conference

Title
International symposium on trends in radiopharmaceuticals
Acronym
ISTR-2005
Dates
14-18 Nov 2005
Place
Vienna (Austria)

INIS

Country of Publication
Austria
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
39066429
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
CHLORAMINES; EXCRETION; IN VITRO; IN VIVO; IODINE 131; LABELLED COMPOUNDS; LIVER; PEPTIDES; RADIOCHEMISTRY; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; STABILITY
Descriptors DEC
AMINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CHEMISTRY; CLEARANCE; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DRUGS; GLANDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANS; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPES

Optional Information

Notes
11 refs, 2 figs, 4 tabs
Secondary number(s)
STI/PUB--1294; IAEA-CN--130