Preparation and biodistribution of 188Re-DTPA
Creators
- 1. Beijing Univ., Beijing (China). Medical Isotopes Research Center
Description
The radiolabeling of diethylenetriaminepentaacetate (DTPA) with 188Re is investigated. Under the optimum conditions, the labeling efficiency of 188Re-DTPA is more than 95% and the in vitro stability of 188Re-DTPA is satisfied. The radiochemical purity of 188Re-DTPA decreases with the increase of dilution ratio of saline solution. The biodistribution of 188Re-DTPA and Na188ReO4 in normal mice is studied. The data reveals that radioactivity levels in the thyroid gland and the stomach are lower in the 188Re-DTPA group than in the Na188ReO4 perrhenate group. The concentration levels in other tissues including lung, liver, testis, muscle, and blood are low throughout this study for both agents. The 188Re-DTPA is excreted primarily via kidney to urine. The result indicates that 188Re-DTPA should be considered as a potential radiopharmaceutical for endovascular irradiation
Additional details
Publishing Information
- Journal Title
- Journal of Nuclear and Radiochemistry
- Journal Volume
- 25
- Journal Issue
- 2
- Journal Page Range
- p. 124-128
- ISSN
- 0253-9950
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 35063233
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BLOOD; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; CLEARANCE; DTPA; LABELLING; PERRHENATES; RADIOPHARMACEUTICALS; RHENIUM 188; SODIUM COMPOUNDS; STABILITY; TISSUE DISTRIBUTION; UPTAKE
- Descriptors DEC
- ALKALI METAL COMPOUNDS; AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY FLUIDS; CARBOXYLIC ACIDS; CHELATING AGENTS; DISTRIBUTION; DRUGS; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; REFRACTORY METAL COMPOUNDS; RESPONSE MODIFYING FACTORS; RHENIUM COMPOUNDS; RHENIUM ISOTOPES; SYNTHESIS; TRANSITION ELEMENT COMPOUNDS; YIELDS