Published 1979
| Version v1
Book
Role of Ca2+ in the binding mechanism of EHDP-Tc complex to bone
- 1. Rijksuniversiteit Leiden (Netherlands). Akademisch Ziekenhuis
Description
Experiments are described testing the hypothesis that 99m-Tc-EHDP complex travels to bone as a unit and dissociates at the bone binding site because of the high affinity of EHDP for hydroxyapatite after which technetium binds separately. The results indicate that technetium is not dissociated from EHDP in binding to hydroxyapatite, but the EHDP-Tc-ligand stays intact. It is postulated that calcium plays an important role in bone-labelling with EHDP-Tc complex and that in fact the EHDP-Ca-Tc complex is the binding agent. Only by assuming the presence of this agent could the action of magnesium-ions or of excess calcium-ions be explained. (Auth./C.F.)
Additional details
Publishing Information
- Publisher
- Elsevier/North-Holland Biomedical Press.
- Imprint Place
- Amsterdam, Netherlands
- ISBN
- 0-444-80178-2
- Imprint Title
- Progress in radiopharmacology
- Imprint Pagination
- 249 p.
- Journal Volume
- 1
- Series
- Progress in Radiopharmacology.
- Journal Page Range
- p. 129-135.
Conference
- Title
- European Symposium on Radiopharmacology.
- Dates
- 21 - 23 Jun 1979.
- Place
- Noordwijkerhout, Netherlands.
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- Netherlands
- INIS RN
- 13674903
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- CALCIUM IONS; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; SKELETON; TECHNETIUM COMPOUNDS; TECHNETIUM 99
- Descriptors DEC
- ATOMIC IONS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CHARGED PARTICLES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPOUNDS; YEARS LIVING RADIOISOTOPES
Optional Information
- Notes
- Imprint:Includes subject index.