The effect of thyroid hormone and bone metablism-associated growth factor on the patients of hyperthyreosis

Objective: To evaluate the effect of high concentration of thyroid hormone and cell growth factor content on the bone metabolism of hyperthyreosis. Methods: Radiation immunological test and chemiluminescence methods are employed to determinate the content of free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), insulin-like growth factor II(IGF-II), calcitonic (CT), interleukin-6 (IL-6) and tumor necrosis factor (TNF) of serum in health adult and parts of hyperthyreosis patients. Results: Hyperthyreosis patients have a higher content of FT4, FT3 and IL-6 than those of health adult (t was 16.69,11.33,7.92, respectively, P<0.01), while the content of TSH, IGF-II, CT, TNF are obvious decreasing (t was 13.08, 8.34, 5.29, 8.75, respectively, P<0.01). Conclusion: In patients with hyperthyreosis, high concentration thyroid hormone cause accentuation of protein metabolism, decrease calcium homeostasis by disorders of phosphorus and calcium metabolism, high concentration thyroid hormone and low level CT resulted in bone loss. Decreased ICF-II may be the main cause of osteoporosis as the result of high concentration thyroid hormone. (authors)