O-alkylation of disodium salt of diethyl 3,4-dihydroxythiophene-2,5-dicarboxylate with 1,2-dichloroethane catalyzed by ionic type phase transfer catalyst and potassium iodide
Creators
- 1. Jiangsu University, Zhenjiang (China)
Description
Diethyl 3,4-ethylenedioxy thiophene-2,5-dicarboxylate was efficiently synthesized via the O-alkylation of disodium salt of diethyl 3,4-dihydroxy thiophene-2,5-dicarboxylate with 1,2-dichloroethane over ionic type phase transfer catalysts, such as tetrabutyl ammonium bromide and benzyl triethyl ammonium chloride. The ionic type phase transfer catalysts showed higher catalytic activities than the nonionic type phase transfer catalysts, such as triethylamine, pyridine, 18-crown-6, and polyethylene glycol 400/600, in the O-alkylation reaction. The conversion of the disodium salt of more than 97% and the selectivity of diethyl 3,4-ethylenedioxy thiophene-2,5-dicarboxylate of more than 98% were achieved when the O-alkylation reaction was synergistically catalyzed by tetrabutyl ammonium bromide and potassium iodide
Additional details
Publishing Information
- Journal Title
- Korean Journal of Chemical Engineering
- Journal Volume
- 31
- Journal Issue
- 1
- Series
- 14 refs, 3 figs, 1 tab
- Journal Page Range
- p. 45-49
- ISSN
- 0256-1115
INIS
- Country of Publication
- Korea, Republic of
- Country of Input or Organization
- Korea, Republic of
- INIS RN
- 47121298
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Descriptors DEI
- AMMONIUM CHLORIDES; BROMIDES; CATALYSTS; POTASSIUM IODIDES; SALTS
- Descriptors DEC
- ALKALI METAL COMPOUNDS; AMMONIUM COMPOUNDS; AMMONIUM HALIDES; BROMINE COMPOUNDS; CHLORIDES; CHLORINE COMPOUNDS; HALIDES; HALOGEN COMPOUNDS; INORGANIC PHOSPHORS; IODIDES; IODINE COMPOUNDS; PHOSPHORS; POTASSIUM COMPOUNDS; POTASSIUM HALIDES