Evaluation of usefulness of 99mTc-GSA liver scintigraphy on hepatic ischemia-reperfusion injury in rats with obstructive jaundice
Creators
- 1. Okayama Univ. (Japan). School of Medicine
Description
99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) is a new liver-imaging agent which binds to hepatic binding protein. This study evaluated the sensitivity of 99mTc-GSA kinetics and imaging anatomy to hepatic ischemia-reperfusion injury of obstructive jaundiced rats. Regional hepatic ischemia was induced by clamping the left hepatic artery and the left portal vein for 45 min. The blood clearance and hepatic accumulation indices were obtained on the basis of the dynamic data. A significant difference of these indices was observed between the ischemic group and the control. Marked depression in hepatic 99mTc-GSA uptake was observed in the ischemic group. In conclusion, 99mtc-GSA is useful for evaluating the hepatic ischemia reperfusion injury in rats with obstructive jaundice. (author)
Additional details
Publishing Information
- Journal Title
- Radioisotopes (Tokyo)
- Journal Volume
- 41
- Journal Issue
- 8
- Journal Page Range
- p. 407-410.
- ISSN
- 0033-8303
- CODEN
- RAISAB
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 24010843
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ALBUMINS; BILIRUBIN; COMPARTMENTS; DTPA; ISCHEMIA; JAUNDICE; LIVER; LIVER CELLS; RADIOPHARMACEUTICALS; RATS; SCINTISCANNING; TECHNETIUM 99; UPTAKE
- Descriptors DEC
- AMINO ACIDS; ANEMIAS; ANIMAL CELLS; ANIMALS; AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CARDIOVASCULAR DISEASES; CHELATING AGENTS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; DRUGS; GLANDS; HEMIC DISEASES; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PIGMENTS; PROTEINS; PYRROLES; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; SOMATIC CELLS; SYMPTOMS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES