HYPOLIPIDEMIC EFFECT OF CURCUMIN OR CO-ENZYME Q1-0 AND THEIR MIXTURE ON OBESE RATS FED A HIGH CHOLESTEROL DIET
Creators
- 1. Zoology Department, Women's College for Arts, Science and Education, Ain Shams University, Cairo (Egypt)
Description
In the current study, hyperlipidemia was induced in the rats by feeding diet enriched with cholesterol for two weeks. After 2 weeks of induction of hypercholesterolemia in rats and in comparison to normal rats, the results showed that incorporation of extra cholesterol in diet led to significant increases in serum cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, leptin and MDA levels. On the other hand, total serum triiodothyronine (T3), liver glutathione (GSH) and glutathione peroxidase (GPx) activities were decreased significantly in cholesterol fed rats. The concentration of TBARS in the liver was elevated.All previous parameters were corrected after the hypercholesterolemic rats were treated with curcumin or co-enzyme Q1-0 or a mixture of them dependent on the time of treatment. These findings are consistent with the concept that curcumin and co-enzyme Q10 are antioxidant agents. The underlying mechanisms of these effects were discussed
Additional details
Publishing Information
- Journal Title
- Isotope and Radiation Research
- Journal Issue
- V.40(4S1
- Journal Page Range
- p. 1205-1219
- ISSN
- 0021-1907
- CODEN
- ISRRAC
INIS
- Country of Publication
- Egypt
- Country of Input or Organization
- Middle Eastern Radioisotope Centre for the Arab Countries (MERRCAC)
- INIS RN
- 40106029
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- BLOOD SERUM; CHOLESTEROL; CURCUMIN; ENZYMES; FEEDING; GLUTATHIONE; LEPTIN; LIVER; RATS; TRIGLYCERIDES
- Descriptors DEC
- ANIMALS; AROMATICS; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; DIGESTIVE SYSTEM; DRUGS; DYES; ESTERS; ETHERS; GLANDS; HORMONES; HYDROXY COMPOUNDS; KETONES; LIPIDS; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; PEPTIDE HORMONES; PEPTIDES; PHENOLS; POLYPEPTIDES; POLYPHENOLS; PROTEINS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; STEROIDS; STEROLS; VERTEBRATES