Published August 2017
| Version v1
Journal article
Synthesis, radiolabeling and preclinical evaluation of a [11C]GMOM derivative as PET radiotracer for the ion channel of the N-methyl-D-aspartate receptor
Creators
- 1. Department of Radiology & Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, P.O. Box 7057, Amsterdam, 1007 MB (Netherlands)
Description
Presently available PET ligands for the NMDAr ion channel generally suffer from fast metabolism. The purpose of this study was to develop a metabolically more stable ligand for the NMDAr ion channel, taking [11C]GMOM ([11C]1) as the lead compound.
Availability note (English)
Available from http://dx.doi.org/10.1016/j.nucmedbio.2017.05.003Additional details
Identifiers
- DOI
- 10.1016/j.nucmedbio.2017.05.003;
- PII
- S0969805117300148;
Publishing Information
- Journal Title
- Nuclear Medicine and Biology
- Journal Volume
- 51
- Journal Page Range
- p. 25-32
- ISSN
- 0969-8051
- CODEN
- NMBIEO
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 51078437
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CARBON 11; EVALUATION; IONS; LABELLING; LEAD COMPOUNDS; LIGANDS; METABOLISM; POSITRON COMPUTED TOMOGRAPHY; RECEPTORS; SYNTHESIS; TRACER TECHNIQUES
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CHARGED PARTICLES; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; MEMBRANE PROTEINS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOISOTOPES; TOMOGRAPHY
Optional Information
- Copyright
- Copyright (c) 2017 The Authors. Published by Elsevier Inc.