Published May 1985
| Version v1
Journal article
Growth delay in 9L rat brain tumor spheroids after irradiation with single and split doses of x rays
- 1. Univ. of California, San Francisco
Description
The response of 9L spheroids to irradiation with single and split doses of X rays has been investigated. Irradiation with single doses caused a dose-dependent decrease in spheroid growth rate, which eventually returned to the growth rate for unirradiated spheroids. This delay appeared to be related to cell survival. When spheroids were irradiated with two 4-Gy doses of X rays separated by various times the amount of growth delay was intermediate between that observed with single doses of 4 and 8 Gy. For relatively short times (15-90 min), recovery probably resulted from repair processes, but for longer times (up to 24 hr), recovery also appeared to depend on cellular redistribution and repopulation effects
Additional details
Publishing Information
- Journal Title
- Radiat. Res.
- Journal Volume
- 102
- Journal Issue
- 2
- Series
- Radiat. Res.
- Journal Page Range
- 182-189
- ISSN
- 0033-7587
- CODEN
- RAREA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 17009203
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ACUTE IRRADIATION; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REPAIR; BRAIN; DOSE-RESPONSE RELATIONSHIPS; FRACTIONATED IRRADIATION; GROWTH; INHIBITION; RATS; SPHEROIDS; TUMOR CELLS; X RADIATION
- Descriptors DEC
- ACUTE EXPOSURE; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; BODY; CENTRAL NERVOUS SYSTEM; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; IRRADIATION; MAMMALS; NERVOUS SYSTEM; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES