Toxicity of GO and rGO suspension against P. acnes: physical puncture and oxidative stress

Acne vulgaris associated with Propionibacterium acnes (P. acnes) remains one of the most common skin diseases, while lacking of effective and non-resistant treatments. Graphene inclusing graphene oxide (GO) and reduced graphene oxide (rGO) have been triggering abundant attentions due to their astonishing performances in multi research areas. Here, the GO and rGO suspensions with different concentrations and sizes against P. acnes were investigated. The higher the concentration while the smaller the size distribution led to the better the antibacterial performance. And the loss of viability of P. acnes can surprisely achieve 72% under a 100 μg 10 000 mesh rGO existed which was induced by physical puncture and oxidative stress. Furthermore, the physiological activities of P. acnes will reduce the GO to rGO which further accelerate its death. This study will provide a rapid, effective and non-resistant method for the treatment of acne. (paper)